Charles Craddock, CBE, FRCP (UK), FRCPath, DPhil, from University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, outlines the breakthrough therapies for the treatment of acute myeloid leukemia (AML) in adults, including midoastaurin in patients with a FLT-3 mutation, vyxeos for patients with secondary AML, and IDH2 inhibitors. This video was recorded at the 2018 European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting in Lisbon, Portugal.