Dr Anderson (Dana Farber Cancer Institute, Boston, USA) chairs a discussion with Prof Palumbo (University of Torina, Torina, Italy), Prof Gareth Morgan (The Royal Marsden Hospital, London, UK), and Prof San Miguel (University Hospital, Salamanca, Spain) at Myeloma 2014 about the treatment of Myeloma. They discuss novel targets and the treatment of high risk disease, and immune based therapy, and provide new insights in drug sensitivity and resistance.