Dana B Cardin, MD, MSCI, Associate Professor of Medicine in the Division of Hematology/Oncology at Vanderbilt University Medical Center. In this video, she speaks about the Trends in the Incidence and Treatment of Early-Onset Pancreatic Cancer.
Observation –
Origins:
Early-onset pancreatic cancer (EOPC) is a rare occurrence. It is unknown whether the prevalence of EOPC is increasing or how these patients are being treated.
Methodologies:
We used SEER 2004-2016 to conduct a retrospective, population-based analysis. We looked examined the annual age-adjusted incidence rate (AAIR), stage at presentation, and race/ethnicity of 7802 individuals, as well as treatment patterns in 7307 patients under the age of 50 (excluding neuroendocrine tumors).
Outcomes:
Males had a higher AAIR, whereas females had a faster rate of rise. The AAIR was highest in non-Hispanic Black patients and rose over time in all races/ethnicities. The percentage of patients diagnosed with distant-stage disease declined throughout time whereas the percentage of individuals diagnosed with localized-stage disease grew. Hispanic patients constituted a greater proportion of patients throughout time than other groups. Primary surgery was the most commonly used form of therapy for localized-stage illness. Chemotherapy with radiation was the most commonly used modality for regional-stage disease from 2004 to 2010, but chemotherapy alone was the most commonly used modality from 2011 to 2016. Chemotherapy alone was the most commonly used treatment for advanced disease and has been used more frequently over time. Adults with EOPC got radiation and chemotherapy at comparable rates to patients 50-69, but underwent surgery more frequently.
Inferences:
The AAIR of EOPC rose over time, with females increasing quicker. EOPC was more prevalent in groups with a higher prevalence of pancreatic cancer, notably African Americans. The treatment of localized and regional-stage pancreatic cancer did not adhere to established pancreatic cancer therapy guidelines. According to our data, EOPC patients received more treatment than their older counterparts.