This is an exciting time for research into the early diagnosis of lung cancer, with a number of promising options on the horizon. Here, Robert Rintoul, PhD, FRCP, of the Cancer Research UK Cambridge Institute, Cambridge, UK, discusses the intriguing work that his group is involved in, investigating the identification of lung cancer via circulating tumor (ct)DNA. Dr Rintoul gives us an overview the study exploring this, which is taking blood samples from patients at multiple timepoints pre- and post-treatment, and emphasizes the important role that a test such as this could serve. This video was recorded at the British Thoracic Oncology Group (BTOG) Annual Conference 2018, held in Dublin, Ireland.