An accurate and optimized clinical scoring system is essential for the staging and management of cutaneous T-cell lymphoma. Here, Pietro Quaglino, MD, of the University of Turin, Turin, Italy, discusses his group’s retrospective study with a proposal for a scoring system for Sézary syndrome, in which particular features correlated with tumor burden and prognosis. This interview was recorded at the European Organisation for the Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Task Force (CLTF) 2018 Congress, held in St. Gallen, Switzerland.