Topical alkylating agents have proven beneficial in treating patients with mycosis fungoides (MF). Here, Martine Bagot, MD, PhD, of Saint Louis Hospital, Paris, France, discusses this topic at the European Organisation for the Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Task Force (CLTF) 2018 Congress, held in St. Gallen, Switzerland. Prof. Baggot covers the access to chlormethine gel in France, and describes its potential in the treatment of early-stage MF as a stand-alone therapy, and in late-stage MF when used as an adjunct treatment.