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Molecular aging and p16INK4a in testicular cancer survivors
00:02:24

Molecular aging and p16INK4a in testicular cancer survivors

Maria Teresa Bourlon, MD, MS, of Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, discusses the link between chemotherapy and premature ageing, via the biomarker p16INK4a, in testicular cancer survivors at the Genitourinary Cancers Symposium 2018, held in San Francisco, CA. Although testicular cancer patients can be cured successfully with chemotherapy, they still suffer from the long-term effects of the treatment. The results of Dr Bourlons research show an increased expression of the p16INK4a senescence protein in patients exposed to chemotherapy. p16INK4a has been found to inhibit CDK4/6 and promote p53 degradation, essentially causing premature senescence. Consequently, testicular cancer survivors may have an increased cancer risk, risk of infection and a weaker response to vaccinations, which is concerning for survivors.
231 Views
5 years Ago
VJ
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Testicular

Jonathan Shamash MBChB, MD, MRCP @NHSBartsHealth @NHSEnglandLDN #TesticularCancer #Cancer #Research The Impact Of A SMDT On Decision- Making in Testicular Cancers
00:25:13
Jonathan Shamash MBChB, MD, MRCP @NHSBartsHealth @NHSEnglandLDN #TesticularCancer #Cancer #Research The Impact Of A S...
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116 Views
Cancer
2 years Ago
Molecular aging and p16INK4a in testicular cancer survivors
00:02:24
Molecular aging and p16INK4a in testicular cancer survivors
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231 Views
VJ
5 years Ago
TIP or BEP for Intermediate or Poor Risk Testicular Cancer?: Highlights in GU Oncology from ASCO 2018 (BMIC-061)
00:03:39
TIP or BEP for Intermediate or Poor Risk Testicular Cancer?: Highlights in GU Oncology from ASCO 2018 (BMIC-061)
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358 Views
H. Jack
5 years Ago

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