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Jan Ole Kemnade, MD, Ph.D. @bcmhouston #ASCO20 Computational discovery of non-mutational tumor-restricted antigens reveals evidence of immunoediting in head and neck squamous cell carcino...
0:11:52

Jan Ole Kemnade, MD, Ph.D. @bcmhouston #ASCO20 Computatio...

Jan Ole Kemnade, MD, Ph.D. from Baylor College of Medicine discusses and ASCO 2020 abstract entitled Computational discovery of non-mutational tumor-restricted antigens reveals evidence of immunoediting in head and neck squamous cell carcinoma

Bottom line:
We previously identified 107 tumor antigens (EbTAgs), defined as genes with negligible expression in healthy tissue and cancer overexpression. EbTAgs present novel adaptive anti-tumor immune response targets and display signs of immunoediting in highly immune oral cavity infiltrated tumors. The EbTAgs expression was contrasted between four HNSCC subtypes in the sense of tumor immune infiltration: oral cavity (OC), HPV+ oropharyngeal (HPV+OP), HPV- oropharyngeal (HPV-OP), and laryngeal / hypopharyngeal (LH) to detail the landscape of EbTAgs in head and neck squamous cell carcinoma (HNSC) and further elucidate EbTAg immunoediting.

Approaches:
For all HNSC samples, the upper quartile FPKM gene expression values of all protein coding genes were determined using RNAseq data from The Cancer Genome Atlas ( TCGA). TCGA HNSC tumors have been classified into subtypes and tested for expression of EbTAg. Using unsupervised clustering of 14 immune cell signature ssGSEA scores for the HNSC dataset as a whole and for each subtype, the individual tumor sample immune infiltrate was calculated.

Reviews:
LH tumors, specifically HPV+OP (p=0.0008, Tukey 's test), exhibited substantially more EbTAgs than other subtypes (p=0.0014). Analysis of the immune clustering found that LH tumors were substantially more likely to be in the lower than the large immune cluster while the opposite was true for tumors with HPV+OP (p<0.0001). Hypothesizing that the expression of EbTAg was a function of tumor immune infiltration rather than a subtype of HNSC, we compared the expression of EbTAg between tumors in low and high immune clusters of the entire HNSC dataset and of each HNSC subset. In contrast with high immune tumors in the HNSC dataset, substantially more EbTAgs were expressed in low immune tumors (p<0.0001). Similarly, substantially more EbTAgs were expressed in low immune tumors relative to high immune tumors in the OC, OP-all tumors, and HPV+OP datasets (p=0.0003, p<0.0001, p=0.0006) with a pattern of more EbTAgs in the HPV-OP and LH datasets (p=0.12, p=0.095) in the immune low versus high tumors.

Findings:  
In TCGA HNSC samples, EbTAg expression correlates with tumor immune infiltration, resulting in lower expression under higher immune strain. These findings support the hypothesis that EbTAgs are immunoedited and are applicable to immunology. Exploration of EbTAgs as antigenic targets of modular or adoptive T-cell therapy vaccines as well as biomarkers of response therapy to immune control point inhibition is warranted.
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2 years Ago
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Ovarian

SOLO-1 Phase 3 [2022]: Newly Diagnosed Advanced Ovarian Cancer
0:12:09
SOLO-1 Phase 3 [2022]: Newly Diagnosed Advanced Ovarian C...
749 Views
6 months Ago
Cancer News
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Podcast Rebecca S. Kristeleit, MD @RKristeleit @GSTTresearch #ASCO22 #OncoTwitter Phase III ATHENA-MONO ASCO Late Breaker
0:08:11
Podcast Rebecca S. Kristeleit, MD @RKristeleit @GSTTresea...
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9 months Ago
Annual Meeting
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Rebecca S. Kristeleit, MD @RKristeleit @GSTTresearch #ASCO22 #OncoTwitter Phase III ATHENA-MONO ASCO Late Breaker
0:08:11
Rebecca S. Kristeleit, MD @RKristeleit @GSTTresearch #ASC...
86 Views
9 months Ago
Annual Meeting
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Podcast Nicole James, PhD @BrownUniversity @womenandinfants #EOC Prognostic Immunologic Signatures In EOC
0:05:13
Podcast Nicole James, PhD @BrownUniversity @womenandinfan...
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11 months Ago
Cancer News
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Nicole James, PhD @BrownUniversity @womenandinfants #EOC Prognostic Immunologic Signatures In EOC
0:05:13
Nicole James, PhD @BrownUniversity @womenandinfants #EOC ...
90 Views
11 months Ago
Cancer News
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Podcast Rebecca S. Kristeleit, MD @RKristeleit @GSTTresearch #ATHENA #OC Phase III ATHENA-MONO Trial
0:08:26
Podcast Rebecca S. Kristeleit, MD @RKristeleit @GSTTresea...
36 Views
12 months Ago
Cancer News
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Rebecca S. Kristeleit, MD @RKristeleit @GSTTresearch #ATHENA #OC Phase III ATHENA-MONO Trial
0:08:26
Rebecca S. Kristeleit, MD @RKristeleit @GSTTresearch #ATH...
88 Views
12 months Ago
Cancer News
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Podcast Bradley J. Monk, MD @GOG #ATHENAMONO #OC ATHENA-MONO Phase III Trial
0:08:07
Podcast Bradley J. Monk, MD @GOG #ATHENAMONO #OC ATHENA-M...
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12 months Ago
Cancer News
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Bradley J. Monk, MD @GOG #ATHENAMONO #OC ATHENA-MONO Phase III Trial
0:08:07
Bradley J. Monk, MD @GOG #ATHENAMONO #OC ATHENA-MONO Phas...
79 Views
12 months Ago
Cancer News
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Podcast - Oliver Dorigo, MD @Stanford @StanfordCancer @imv_inc #ASCOPubs #ESMO2021 #OvarianCancer #Cancer #Research DeCidE1 Clinical Trial in Advanced Recurrent Ovarian Cancer and the upd...
0:12:35
Podcast - Oliver Dorigo, MD @Stanford @StanfordCancer @im...
71 Views
1 year Ago
Cancer News
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Oliver Dorigo, MD @Stanford @StanfordCancer @imv_inc #ASCOPubs #ESMO2021 #OvarianCancer #Cancer #Research DeCidE1 Clinical Trial in Advanced Recurrent Ovarian Cancer and the updated data ...
0:12:35
Oliver Dorigo, MD @Stanford @StanfordCancer @imv_inc #ASC...
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1 year Ago
Cancer News
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Podcast - David M. O'Malley, MD @omalleygynonc @OhioStateMed @OSUCCC_James #OvarianCancer #Cancer #Research Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer
0:11:53
Podcast - David M. O'Malley, MD @omalleygynonc @OhioState...
14 Views
1 year Ago
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