Symptom burden in patients with myeloproliferative neoplasms (MPNs), in the form of fatigue, night sweats and weight loss, can remain severe even with the newest treatments. In this video, recorded at the 23rd Congress of the European Hematology Association (EHA) 2018, held in Stockholm, Sweden, Ruben Mesa, MD, of UT Health San Antonio Cancer Center, San Antonio, TX, discusses the role of non-pharmaceutical interventions in reducing the impact of symptoms on quality of life alongside continued treatment. He speaks about a recent trial exploring the impact of an online, specialized yoga module on MPN patient symptoms, and the findings that this program reduces fatigue, depression and even inflammation. With these positive results, Dr Mesa plans to create a whole toolkit of non-pharmaceutical interventions, including meditation and nutritional advice, to better equip MPN patients in future.