In this session, Thomas Habermann, MD, of the Mayo Clinic, Rochester, MI, chairs a discussion with Bjoern Chapuy, PhD, MD, from the Dana-Farber Cancer Institute, Boston, MA, and Nicolas Ortonne, MD, PhD, of Henri Mondor University Hospital, Créteil, France. The group explore actionable genetic signatures for diffuse large B-cell lymphoma, and biomarkers for the diagnosis and treatment of cutaneous T-cell lymphoma. This discussion was recorded at the International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2018 meeting, held in Nice, France.