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Erin Murphy, MD  @ErinMurphyMD @ClevelandClinic #ClevelandClinicChildrens #Glioma #Cancer #Research Neurocognitive Function Following Concurrent Radiotherapy and Temozolomide for Adult Pa...
0:05:12

Erin Murphy, MD @ErinMurphyMD @ClevelandClinic #Clevelan...

Erin Murphy, MD Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic speaks about ASTRO 2021 Abstract - 3258 Neurocognitive Function Following Concurrent Radiotherapy and Temozolomide for Adult Patients With Low-Grade Glioma.

Link to Abstract:
https://plan.core-apps.com/myastroapp2021/abstract/27f970a0-a161-48c6-adc4-064924c2d044

Case:

Goal:

RTOG 0424 showed that patients with high-risk low-grade glioma (LGG) who received concurrent temozolomide (TMZ) and radiation (RT) followed by adjuvant temozolomide (RT+TMZ) had a longer life than historical controls. The long-term effects of this therapy method on neurocognitive results are unknown. We wanted to see how neurocognitive parameters changed in adult LGG patients before and after RT+TMZ.

Components:

We looked at 22 LGG patients who had been treated with RT and TMZ after surgery. Pre- and post-treatment neurocognitive batteries were used. Learning and memory were measured verbally (Hopkins Verbal Learning Test [HVLT]) and nonverbally (Brief Visuospatial Memory Test [BVMT]), as well as motor functioning (Grooved Pegboard Test) and phonemic fluency (CFL). For paired samples, a nonparametric paired t-test (Wilcoxon signed ranked test) was used with post-treatments of within 3 months (14 pairs) and after 3 months (12 pairs). R 4.0.3 was used for all of the statistical analysis.

Findings:

The median age at diagnosis was 43 (range: 23-77), and 18 (82 percent) of the patients were men. IDHmut-1p19q-codel, IDHmut-1p19q-noncodel, IDHmut-NOS, IDH1-R132H-negative, and unknown were found in 3 (14%) patients, 1 (5%), 11 (50%) patients, and 4 (18%) patients, respectively, according to molecular classification. Three patients (14%) had a gross entire resection, two (9%) had a near total resection, six (27%) had a subtotal resection, and eleven (11%) had a biopsy (50 percent ). Within three months of undergoing RT+TMZ, patients showed no significant decline in nonverbal learning (BVMT total recall, P = 0.67, n=14) or verbal learning or memory (HVLT, P = 0.06, n=14). Nonverbal learning and verbal learning/memory, both tested > 3 months after treatment completion, showed no significant reduction (P = 0.62, n=12; P = 0.67, n=12). Within 3 months of treatment (P = 0.84, n=14; P = 0.26, n=14) and after 3 months (P = 0.94, n=12; P = 0.09, n=12), motor function (Grooved Pegboard, both dominant and non-dominant) remained steady. Within 3 months of treatment (P = 0.083, n=14) or after 3 months (P = 0.67, n=12), phonemic fluency (CFL) did not demonstrate a significant drop.

Outcome:

When compared to their pre-radiation baseline, adult LGG patients showed no subacute significant changes in verbal and nonverbal memory, motor function, or phonemic fluency after RT+TMZ. To determine the neurocognitive impact of this therapy method, bigger sample size and longer follow-up are required.

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1 year Ago
ASTRO
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Brain

What is VAL-083? Dennis Brown [2022]: Key Glioblastoma Facts
What is VAL-083? Dennis Brown [2022]: Key Glioblastoma Facts
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3 months Ago
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VAL-083: Dennis Brown [2022]: Key Facts To Consider Glioblastoma
0:11:08
VAL-083: Dennis Brown [2022]: Key Facts To Consider Gliob...
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Podcast Julie Wu, MD, PhD @julie_t_wu @Stanford #IASLC22 #BrainMetastasis Molecular Driver Mutations In Brain Metastasis
0:09:16
Podcast Julie Wu, MD, PhD @julie_t_wu @Stanford #IASLC22 ...
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12 months Ago
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Julie Wu, MD, PhD @julie_t_wu @Stanford #IASLC22 #BrainMetastasis Molecular Driver Mutations In Brain Metastasis
0:09:16
Julie Wu, MD, PhD @julie_t_wu @Stanford #IASLC22 #BrainMe...
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12 months Ago
Rob
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Podcast David Schiff, MD @uvahealthnews @UVACancerCenter #BrainMetastases New Guidelines Treatment: Brain Metastases
0:08:18
Podcast David Schiff, MD @uvahealthnews @UVACancerCenter ...
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1 year Ago
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David Schiff, MD @uvahealthnews @UVACancerCenter #BrainMetastases New Guidelines Treatment: Brain Metastases
0:08:18
David Schiff, MD @uvahealthnews @UVACancerCenter #BrainMe...
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1 year Ago
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Podcast - Erin Murphy, MD  @ErinMurphyMD @ClevelandClinic #ClevelandClinicChildrens #Glioma #Cancer #Research Neurocognitive Function Following Concurrent Radiotherapy and Temozolomide fo...
0:05:12
Podcast - Erin Murphy, MD @ErinMurphyMD @ClevelandClinic...
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1 year Ago
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Erin Murphy, MD  @ErinMurphyMD @ClevelandClinic #ClevelandClinicChildrens #Glioma #Cancer #Research Neurocognitive Function Following Concurrent Radiotherapy and Temozolomide for Adult Pa...
0:05:12
Erin Murphy, MD @ErinMurphyMD @ClevelandClinic #Clevelan...
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1 year Ago
ASTRO
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Podcast - Samuel Chao, MD @SamuelChaoMD @ClevelandClinic @caseccc #ASTRO21 #braincancer Fluciclovine PET/CT to Distinguish Radiation Necrosis From Tumor Progression in Brain Metastases
0:06:28
Podcast - Samuel Chao, MD @SamuelChaoMD @ClevelandClinic ...
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1 year Ago
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Samuel Chao, MD @SamuelChaoMD @ClevelandClinic @caseccc #ASTRO21 #braincancer Fluciclovine PET/CT to Distinguish Radiation Necrosis From Tumor Progression in Brain Metastases
0:06:28
Samuel Chao, MD @SamuelChaoMD @ClevelandClinic @caseccc #...
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1 year Ago
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Podcast - Yanhong Shi, PhD @cityofhope @cityofhopeOC #GlioblastomaTumorigenesis #CityofHope #Cancer #Research Targeting PUS7 Suppresses tRNA Pseudouridylation And Glioblastoma Tumorigenesis
0:05:48
Podcast - Yanhong Shi, PhD @cityofhope @cityofhopeOC #Gli...
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Podcast - Sarah E- S- Leary, MD @seattlechildrens #childrensmedulloblastoma #medulloblastoma #Cancer #Research Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medullob...
0:05:17
Podcast - Sarah E- S- Leary, MD @seattlechildrens #childr...
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