Author: Editor

Shinji Atagi, MD of National Hospital Organization Kinki-Chuo Chest Medical Center gives an overview of a randomized trial done by the Japan Clinical Oncology Group on radiotherapy for elderly NSCLC patients. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 8532: Randomized trial of thoracic radiotherapy with or without concurrent daily low-dose carboplatin in elderly patients with locally advanced non-small cell lung cancer (NSCLC): Long-term follow-up of Japan Clinical Oncology Group (JCOG) Study JCOG0301

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David Michael Hyman, MD of Memorial Sloan-Kettering talks of his hopes for LOXO-101 in future clinical practice and clinical trials at the 2017 ASCO Annual Meeting in Chicago, IL. LBA2501: The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers

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David Michael Hyman, MD of Memorial Sloan-Kettering gives an overview his presentation, which focuses on the efficacy of larotrectinib (LOXO-101) in adult and pediatric TRK fusion cancers at the 2017 ASCO Annual Meeting in Chicago, IL. LBA2501: The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers.

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David Michael Hyman, MD of Memorial Sloan-Kettering explains common questions physicians ask him concerning his study on the efficacy of larotrectinib (LOXO-101). This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. LBA2501: The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers

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William P. Harris, MD of Seattle Cancer Care Alliance explains some of the common questions asked regarding the phase II trial on pancreatic cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 4008: Randomized phase II study of PEGPH20 plus nab-paclitaxel/gemcitabine (PAG) vs AG in patients (Pts) with untreated, metastatic pancreatic ductal adenocarcinoma (mPDA).

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Julie R. Gralow, MD of Seattle Cancer Care Alliance explains the impact of the trial on clinical practice, arguing that the data now shows the important role PARP inhibitors have in metastatic breast cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 521: SWOG S0221 updated: Randomized comparison of chemotherapy schedules in breast cancer adjuvant therapy

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Davendra Sohal, MD of Cleveland Clinic gives an overview of his presentation, Perioperative mFOLFIRINOX vs. Gemcitabine/nab-Paclitaxel as Therapy for Resectable Pancreatic Adenocarcinoma, which was discussed at the 2017 ASCO Annual Meeting in Chicago, IL. TPS4152: Perioperative mFOLFIRINOX vs. Gemcitabine/nab-Paclitaxel as Therapy for Resectable Pancreatic Adenocarcinoma

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Jason A. Chesney, MD, PhD of the James Graham Brown Cancer Center discusses the impact of the talimogene laherparepvec and ipilimumab combination in melanoma. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9509: Primary results from a randomized (1:1), open-label phase II study of talimogene laherparepvec (T) and ipilimumab (I) vs I alone in unresected stage IIIB- IV melanoma

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Jason A. Chesney, MD, PhD of the James Graham Brown Cancer Center discusses the most exciting and interesting presentations coming out of ASCO 2017, which include three oral presentations, focusing on the efficacy of FDA-approved combination regiments in melanoma patients who have brain metastases. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL.

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Jason A. Chesney, MD, PhD of the James Graham Brown Cancer Center talks of the common questions most physicians ask regarding his study on talimogene laherparepvec and ipilimumab in melanoma. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9509: Primary results from a randomized (1:1), open-label phase II study of talimogene laherparepvec (T) and ipilimumab (I) vs I alone in unresected stage IIIB- IV melanoma

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Jason A. Chesney, MD, PhD of the James Graham Brown Cancer Center gives an overview of his presentation which focused on the use of talimogene laherparepvec and ipilimumab versus ipilimumab alone in melanoma. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9509: Primary results from a randomized (1:1), open-label phase II study of talimogene laherparepvec (T) and ipilimumab (I) vs I alone in unresected stage IIIB- IV melanoma

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Bernardo H. Goulart, MD, MS of Seattle Cancer Care Alliance explains the impact of natural language processing (NLP) on future clinical practice and trials. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 6528: Validation of natural language processing (NLP) for automated ascertainment of EGFR and ALK tests in SEER cases of non-small cell lung cancer (NSCLC).

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Bernardo H. Goulart, MD, MS of Seattle Cancer Care Alliance discusses the use of natural language processing (NLP) for patients with non-small cell lung cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 6528: Validation of natural language processing (NLP) for automated ascertainment of EGFR and ALK tests in SEER cases of non-small cell lung cancer (NSCLC).

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Michael J. Birrer, MD, PhD, Director of the University of Alabama at Birmingham Comprehensive Cancer Center gives an overview of his current clinical studies, which focus on the use of mirvetuximab soravtansine for platinum-resistant epithelial ovarian cancer patients Abstract 5547: Mirvetuximab soravtansine (IMGN853), a folate receptor alpha (FR?)-targeting antibody-drug conjugate (ADC), in platinum-resistant epithelial ovarian cancer (EOC) patients (pts): Activity and safety analyses in phase I pooled expansion cohorts Abstract TPS5607: FORWARD I (GOG 3011): A randomized phase 3 study to evaluate the safety and efficacy of mirvetuximab soravtansine (IMGN853) versus chemotherapy in adults with folate receptor alpha (FR?)-positive, platinum-resistant…

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Michael J. Birrer, MD, PhD, Director of the University of Alabama at Birmingham Comprehensive Cancer Center discusses a collaborated study with Dr. Dr. Jalid Sehouli of AGO and Charité Campus Virchow-Klinikum, Berlin, Germany, that focuses on the clinical characteristics of long-term ovarian cancer survivors. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract e17063: Clinical characterization of long term survivors (LTS) in ovarian cancer (OC): Results of a propensity score matched (PSM) analysis of the international prospective tumor bank for ovarian cancer (TOC Network)

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Michael J. Birrer, MD, PhD, Director of the University of Alabama at Birmingham Comprehensive Cancer Center gives an overview of presentation that involves the use of avelumab in patients with endometrial cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract TPS5615: Phase 2, two-group, two-stage, open-label study of avelumab in patients with microsatellite stable, microsatellite instable and POLE-mutated recurrent or persistent endometrial cancer

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Manmeet S. Ahluwalia, MD of Cleveland Clinic discusses three abstracts presented at ASCO 2017, highlighting the management of brain metastases in melanoma. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9506: COMBI-MB: A phase II study of combination dabrafenib (D) and trametinib (T) in patients (pts) with BRAF V600mutant (mut) melanoma brain metastases (MBM) presented by Dr. Michael A. Davies of MD Anderson Cancer Center Abstract 9507: Efficacy and safety of nivolumab (NIVO) plus ipilimumab (IPI) in patients with melanoma (MEL) metastatic to the brain: Results of the phase II study CheckMate 204 presented by…

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Vivek Subbiah, MD of MD Anderson Cancer Center discusses the impact of his study of vemurafenib in NSCLC patients on clinical practice and future clinical research. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9074: Efficacy of vemurafenib in patients (pts) with non-small cell lung cancer (NSCLC) with BRAFV600mutation.

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Mizuki Nishino, MD, MPH of Dana-Farber Cancer Institute gives an overview of her presentation, Tumor response dynamics of advanced non-small-cell lung cancer (NSCLC) patients (pts) treated with commercial PD-1 inhibitors in the clinical setting, which was presented at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9087: Tumor response dynamics of advanced non-small-cell lung cancer (NSCLC) patients (pts) treated with commercial PD-1 inhibitors in the clinical setting.

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Alok Khorana, MD of Cleveland Clinic gives an overview his presentation, which focuses on time to initiating (TTI) cancer therapy for common solid tumors. Data suggests an increase in TTI is associated with substantial increase in mortality. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 6557: Time To Initiating Cancer Therapy Is Increasing And Associated With Worsened Survival In Curative Settings: A US Analysis of Common Solid Tumors

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Daniel A. Goldstein, MD of Davidoff Cancer Center explains the questions regarding the equivalence of dosing in milligrams versus milligrams per kilograms. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9013: A phamacoeconomic analysis of personalized dosing versus fixed dosing of pembrolizumab in first-line PD-L1 positive non-small cell lung cancer.

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Daniel A. Goldstein, MD of Davidoff Cancer Center gives an overview of his presentation, involving dosing of pembrolizumab in non-small cell lung cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9013: A phamacoeconomic analysis of personalized dosing versus fixed dosing of pembrolizumab in first-line PD-L1 positive non-small cell lung cancer

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Brian Slomovitz, MD of University of Miami Health System and Sylvester Comprehensive Cancer Center explains the goal of the AIM2CERV trial, which is to evaluate whether or not axalimogene filolisbac can prevent or reduce the risk of cervical cancer recurrence after patients received the initial standard of care. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL.

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Briggs Morrison MD, CEO of Syndax Pharmaceuticals, Inc. discusses the most common questions he has been asked regarding the ENCORE study, which are: what are the characteristics of the patients that went into the study, how long has it been since the patients progressed, and are these patients who initially had a response and then progress? This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL.

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Krishnansu S. Tewari, MD of University of California, Irvine explains what CA4P is. CA4P is a vascular disrupting agent (VDA), which is thought to work by blocking the blood supply inside the tumor, depriving it of oxygen and nutrients, which leads to cell death. CA4P is being developed by Mateon Therapeutics in South San Francisco, CA. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL.

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Krishnansu S. Tewari, MD of University of California, Irvine discusses the most recent results from the FOCUS trial, including the first interim analysis which evaluated the safety of the drug as well as early signs of efficacy. The trial is sponsored by Mateon Therapeutics in South San Francisco, CA This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL.

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Krishnansu S. Tewari, MD of University of California, Irvine gives an overview of the FOCUS trial, which is sponsored by Mateon Therapeutics in South San Francisco, CA. The FOCUS trial is a double-blind, randomized, phase 2/3 clinical study evaluating the efficacy and safety of physicians choice chemotherapy plus bevacizumab and CA4P versus physicians choice chemotherapy plus bevacizumab and placebo in patients with platinum-resistant ovarian cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL

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Mark Rutstein, Vice President of Oncology Development of Bayer gives an overview of three abstracts that discussed the use of regorafenib (stivarga) in advanced colorectal cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract #3567: Impact of tumor location on outcomes in patients with metastatic colorectal cancer (mCRC) treated with regorafenib (REG): An interim analysis from the prospective, observational CORRELATE study Abstract #3551: Handfoot skin reaction (HFSR) and outcomes in the phase 3 CORRECT trial of regorafenib for metastatic colorectal cancer (mCRC) Abstract #4078: Efficacy of regorafenib (REG) in patients with hepatocellular carcinoma (HCC) in…

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Mark Rutstein, Vice President of Oncology Development of Bayer discusses the RIFTOS trial, which focused on the use of sorafenib for thyroid cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract #6084: Interim baseline characteristics from RIFTOS MKI, a global non-interventional study assessing the use of multikinase inhibitors (MKIs) in the treatment of patients with asymptomatic radioactive iodine-refractory differentiated thyroid cancer (RAI-R DTC)

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Mark Rutstein, Vice President of Oncology Development of Bayer gives an overview of two poster presentations that focus on the use of Copanlisib for relapsed or refractory follicular lymphoma and relapsed or refractory diffuse large B-cell lymphoma (DLBCL). This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Poster #7535: Copanlisib in patients with relapsed or refractory follicular lymphoma Poster #7536: Phase II study of single-agent copanlisib in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).

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Mark Rutstein, Vice President of Oncology Development of Bayer gives an overview of the ARASENS study, which is a phase 3 trial on the use of darolutamide for men with metastatic hormone-sensitive prostate cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract #TPS5092: ARASENS phase 3 trial of ODM-201 in men with metastatic hormone-sensitive prostate cancer (mHSPC)

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David Ilson, MD, PhD of Memorial Sloan-Kettering gives an overview of his presentation, Debate: Does Radiation Therapy Play a Role in Gastric Cancer Adjuvant Therapy, which was debated with Dr. Christopher Crane, MD of Memorial Sloan-Kettering. He argues that adjuvant radiation therapy adds no benefit to treatment. This was recorded at the 2017 Great Debates and Updates in GI Malignancies in New York, NY.

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Yelena Yuriy Janjigian, MD of Memorial Sloan-Kettering explains whether or not PDL-1 is a sufficient biomarker in gastric disease. She argues that clinicians should consider a one-stop next generation sequencing. This was recorded at the 2017 Great Debates and Updates in GI Malignancies in New York, New York.

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Tanios S. Bekaii-Saab, MD, FACP of Mayo Clinic explains whether or not there is a standard second line treatment for patients with hepatocellular carcinoma (HCC) and who failed first line therapy. He argues that Regorafenib should be used for second line therapy. This was recorded at the 2017 Great Debates and Updates in GI Malignancies in New York, NY.

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Christopher Leigh Hallemeier, MD of Mayo Clinic gives an overview of Dr. Julio Garcia-Aguilar’s latest research trial, A Phase II Multicenter Randomized Trial Evaluating 3-year Disease Free Survival in Patients with Locally Advanced Rectal Cancer Treated with Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management, at the 2017 Great Debates and Updates in GI Malignancies in New York, NY.

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Angela R. Bradbury, MD of Perelman School of Medicine at the University of Pennsylvania discusses the integration of information on genetic testing into clinical care. She states that with more discussion on genetic testing, more patients will be encouraged to receive testing. This was recorded at ASCO’s 2017 Cancer Survivorship Symposium in San Diego, CA.

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Grant Stewart, MBChB, FRCSEd (Urol), PhD, from the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK, discusses novel treatments for renal cell carcinoma (RCC) at the European Association of Urology (EAU) conference 2017 in London, UK. He highlights the efficacy of combination therapies which can enhance the efficacy of known drugs. Dr Stewart also describes challenges associated with having multiple combination approaches available, and speaks about new approaches to identify good drug combinations.

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Gerald Mickisch, MD, from the Bremen Center of Operative Urology, Bremen, Germany, discusses how sequential therapy can be used in the treatment of castration-resistant prostate cancer at the European Association of Urology (EAU) conference 2017 in London, UK. Prof. Mickisch explains the efficacy of sequential therapy, and speaks about the order in which treatments are typically given to improve overall survival (OS).

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Bertrand Tombal, MD, PhD, Catholic University of Leuven, Leuven, Belgium, discusses the ARASENS trial for prostate cancer at the European Association of Urology (EAU) conference 2017 in London, UK. He highlights the three pillars of prostate cancer treatment: androgen deprivation therapy, androgen receptor suppression, and chemotherapy. Prof. Tombal introduces the hypothesis that combining these treatments will improve overall survival (OS), on which the Phase III ARASENS trial (NCT02799602) is based, and outlines the design of this study.

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Anne Kiltie, MD, MRCP(UK), FRCR, from the University of Oxford, Oxford, UK, discusses bladder preservation in muscle invasive bladder cancer at the European Association of Urology (EAU) conference 2017 in London, UK. She describes bladder sparing approaches using a combination of chemotherapy and radiotherapy before carrying out surgery to remove the bladder, and how these vary between different countries. Prof. Kiltie highlights her interest in the treatment of elderly patients, for whom not all therapy options may be available.

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Morgan Roupret, MD, PhD, from the Pitié-Salpétrière Hospital, Paris, France, discusses what uro-oncologists should know about new drugs in 2017 at the European Association of Urology (EAU) conference 2017 in London, UK. Prof. Roupret highlights the importance of clinical implications, and explains why clinicians should be informed about what is most important in the management of the disease and treatment side effects.

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Morgan Roupret, MD, PhD, from the Pitié-Salpétrière Hospital, Paris, France, discusses optimization of contemporary bladder cancer care at the European Association of Urology (EAU) conference 2017 in London, UK. He highlights that bladder cancer has been treated with the same tools for over 30 years, and speaks about new therapies which are now available. Prof. Roupret also points out why a multidisciplinary team approach is needed for bladder cancer management.

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Mark Emberton, MD, FRCS Urol, from University College London Hospitals NHS Foundation Trust, London, UK, discusses the potential of intraprostatic PRX302 injection for prostate cancer at the European Association of Urology (EAU) conference 2017 in London, UK. He highlights the advantages of imaging technologies to visualize the tumor, and speaks about how this allows localized treatment to be carried out and what this means for the patient. Prof. Emberton describes different approaches for targeting the tumor, including energy sources and pharmaceutical approaches, and outlines how the effects of the bacterial toxin PRX302 can be limited to the prostate. He speaks…

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In this presentation from the 21st Annual Perspectives in Thoracic Oncology, Dr. Corey J. Langer discusses the targeting of angiogenesis in non-small cell lung cancer (NSCLC). Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=Lung © 2017 Imedex, LLC.

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In this presentation from the 21st Annual Perspectives in Thoracic Oncology, Dr. Ranee Mehra discusses the management of T790-negative EGFR-mutated non-small cell lung cancer (NSCLC). Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=Lung © 2017 Imedex, LLC.

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In this presentation from the 21st Annual Perspectives in Thoracic Oncology, Dr. Tracey L. Evans discusses the management of T790-positive EGFR-mutated non-small cell lung cancer (NSCLC). Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=Lung © 2017 Imedex, LLC.

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In this discussion, the co-chairs of the European Focus on Myeloproliferative Neoplasms & Myelodysplastic Syndromes 2017 highlight the key points presented during the meeting, with the aim of sharing updates that will help you enhance your clinical practice. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=EMDS © 2017 Imedex, LLC.

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Gokul Das, PhD of Roswell Park, Department of Pharmacology and Therapeutics discusses how to customize therapy based on the stratification of p53. He further explains with the stratification of p53 status, clinicians can now come up with new strategies for treatment. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Valerie M. Weaver, PhD of UCSF Medical Center discusses the research on tumor microenvironment and its impact on cancer research and overall standard of care. She argues the research data helps predict potential tumors and can potentially develop novel pathways and novel treatments to help lower risk in patients. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Solange Peters, MD, PhD of Lausanne University Hospital discusses the impact of Checkmate-026 on current cancer research, stating the data encourages clinicians to move and assess the biomarkers in all ongoing trials. She also argues that the biomarker can help predict which patients will benefit from early therapeutic treatments. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Solange Peters, MD, PhD of Lausanne University Hospital gives an overview of her presentation, Impact of tumor mutation burden on the efficacy of first-line nivolumab in stage IV or recurrent non-small cell lung cancer: an exploratory analysis of CheckMate -026, which was discussed at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Suzanne L. Topalian, MD of Johns Hopkins Kimmel Comprehensive Cancer Center gives an overview of presentations that were discussed at the AACR 2017 annual meeting. She describes the use of immune checkpoint blocking drugs in four different types of cancers: breast cancer, melanoma, merkel cell carcinoma, and lung cancer. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Suzanne L. Topalian, MD of Johns Hopkins Kimmel Comprehensive Cancer Center gives an overview of the AACR presentations, which focused greatly on immunotherapy, biomarkers, and combinations. She further explains the impact of immunotherapy on all types of cancer treatments. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Kazuaki Takabe, MD, PhD of Roswell Park Cancer Institute describes the lack of immunotherapy in treatment for breast cancer, stating the biggest challenge in breast cancer research is figuring out a way to utilize immunotherapy in treatments. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Jonathan D. Powell, MD, PhD of Johns Hopkins University, School of Medicine explains what types of tumors would the new drug be useful for? He argues that the new agent would be useful for all tumors since all tumors rely on a specialized metabolism in order to grow. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Jonathan D. Powell, MD, PhD of Johns Hopkins University, School of Medicine explains the importance of targeting metabolism for cancer research. He argues by targeting metabolic pathways, selective tumor cells will be killed, which will enhance not only cancer treatments but immunotherapy as well. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Mateusz Opyrchal, MD, PhD of Roswell Park Cancer Institute discusses how the data from the AURKA study shows a possibility in combination therapy between MAPK pathway and other inhibitors. He states the future of clinical trials will revolve around this type of combination study. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Richard Koya, MD, PhD of Roswell Park Cancer Institute explains the significance of how tumors evolve from one type of mutation to another. He states that if there is a better understanding of tumor evolution and mutation, clinicians can gain an idea of what needs to be targeted in the future. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Richard Koya, MD, PhD of Roswell Park Cancer Institute gives an overview of his presentation, Sustained efficacy of immunotherapy for solid tumors with novel dual CD4/CD8 T cell receptor engineered synergistic combination of hematopoietic stem cells and T cells, which was presented at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Richard Koya, MD, PhD of Roswell Park Cancer Institute explains how the new data on T-Cell receptors impacts next generation for immunotherapies. He argues how the harnessing of t-cell receptors to recognize cancer cells will benefit future clinical trials. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Howard L. Kaufman, MD, FACS of Rutgers Cancer Institute of New Jersey explains whether or not there is a biomarker to better predict which patients respond to treatment. He states there have been studies for potential biomarkers, but none of the data showed significant responses. He advises all patients should undergo this treatment until clinicians find a biomarker. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Howard L. Kaufman, MD, FACS of Rutgers Cancer Institute of New Jersey explains the impact of data on future research, stating that avelumab is the only FDA approved drug for Merkel Cell Carcinoma, and with moving forward, future research will involve immunotherapy and combination therapy. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Jean-Pierre J. Issa, MD of Fox Chase Cancer Center Fels Institute for Cancer Research & Molecular Biology at Temple University discusses the treatment trends in 2017 for patients with MDS and AML, which include introduction of new agents, combination therapy, and immunotherapy. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Jean-Pierre J. Issa, MD of Fox Chase Cancer Center Fels Institute for Cancer Research & Molecular Biology at Temple University explains how the impact of epigenetic therapy could lead to more randomized studies and new standard of care for patients with MDS and AML. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Jean-Pierre J. Issa, MD of Fox Chase Cancer Center Fels Institute for Cancer Research & Molecular Biology at Temple University gives an overview of presentations at AACR 2017, specifically on immunotherapy. He states that in order to make immunotherapy work better for patients, the idea of combining immunotherapy with epigenetic therapy is a possibility moving forward. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Jean-Pierre J. Issa, MD of Fox Chase Cancer Center Fels Institute for Cancer Research & Molecular Biology at Temple University discusses questions of concern on the the toxicity of the new epigenetic drugs and speculation on what happens after treatment with these drugs. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Jean-Pierre J. Issa, MD of Fox Chase Cancer Center Fels Institute for Cancer Research & Molecular Biology at Temple University discusses the importance of discovering and evaluating new epigenetic drugs for cancer research. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Kishore Guda, DMV, PhD of Case Western Reserve University gives an overview of his presentation, Mutational Landscapes of African American Colon Cancers. His presentation was a part of the ‘Minorities in Cancer Research Scientific Symposium: The Role of Diverse Populations in Precision Medicine’ session at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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Kishore Guda, DMV, PhD of Case Western Reserve University discusses the existing social stigmas for ethnic populations in cancer research. He hopes to educate healthcare professionals by removing these misconceptions which will ultimately benefit all diverse groups. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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David Goodrich, PhD of Roswell Park Cancer Institute, Department of Pharmacology and Therapeutics explains the transformation of cancers into stem-cell phenotypes, which allows them to adapt to different therapies. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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David Goodrich, PhD of Roswell Park Cancer Institute, Department of Pharmacology and Therapeutics discusses the treatment trends for prostate cancer in 2017 and gives an overview of an AACR session, which focused on the “Hallmarks of Cancer” and the epigenetic phenomenon that is occurring in cancer research. This was recorded at the American Association for Cancer Research (AACR) 2017 Annual Meeting in Washington, DC.

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In this presentation from the 14th Annual Best of San Antonio – Breast Cancer: Bench to Bedside, Dr. Eric P. Winer looks back at the advances made in the treatment of breast cancer in the last few decades in an effort to elucidate how to best move forward in 2017. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7244 © 2017 Imedex, LLC.

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Cynthia Macahilig of the University of Manchester discusses Health-Related Quality of Life, Treatment Satisfaction, and Work Productivity for Patients With Advanced Renal Cell Carcinoma in a Chart Review Across Six Countries  12th European International Kidney Cancer Symposium 2017

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Hans J. Hammers, MD of the University of Texas Southwestern Medical Center discusses Updated Results From a Phase I Study of Nivolumab in Combination With Ipilimumab in Metastatic Renal Cell Carcinoma: The CheckMate 016 Study from the  12th European International Kidney Cancer Symposium 2017

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In this activity, meeting co-chair Dr. John P. Leonard provides the key take-home messages from the leukemia, myeloid disorders, and benign hematology sessions at the 2017 Great Debates & Updates in Hematologic Malignancies, held April 7-8, 2017. Earn CME Credit for this activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7254 © 2017 Imedex, LLC.

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In this presentation from the 14th Annual Best of San Antonio – Breast Cancer: Bench to Bedside, Dr. Kathy S. Albain discusses updates in adjuvant and neoadjuvant therapy for the treatment of breast cancer, and elaborates on the latest data on predictors of benefit. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7244 © 2017 Imedex, LLC.

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In this presentation from the 14th Annual Best of San Antonio – Breast Cancer: Bench to Bedside, Dr. Debu Tripathy discusses novel therapeutics for the treatment of breast cancer, with a focus on HER2+ and triple negative disease. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7244 © 2017 Imedex, LLC.

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In this presentation from the 14th Annual Best of San Antonio – Breast Cancer: Bench to Bedside, Dr. Hope S. Rugo discusses novel therapeutics for the treatment of breast cancer, with a focus on CDK inhibitors, immunotherapy, and the role of tumor infiltrating lymphocytes. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7244 © 2017 Imedex, LLC.

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In this activity, meeting co-chair Dr. David P. Steensma provides the key take-home messages from the leukemia, myeloid disorders, and benign hematology sessions at the 2017 Great Debates & Updates in Hematologic Malignancies, held April 7-8, 2017. Earn CME Credit for this activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7253 © 2017 Imedex, LLC.

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In this activity, meeting co-chair Dr. Robert Z. Orlowski provides the key take-home messages from the plasma cell disorder session at the 2017 Great Debates & Updates in Hematologic Malignancies, held April 7-8, 2017. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7252 © 2017 Imedex, LLC.

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