Author: Editor

As part of a recent MPN Town Meeting in partnership with Robert H. Lurie Comprehensive Cancer Center in Chicago, Drs. Brady Stein and Naveen Pemmaraju discuss how myeloproliferative neoplasms (MPNs)essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) are diagnosed. The experts discuss the necessary blood tests, including platelet counts, and provide a thorough explanation of bone marrow biopsy. Get email alerts | http://www.patientpower.info/alerts Subscribe on YouTube | http://www.youtube.com/patientpower Like on Facebook | http://www.fb.com/patientpower.info Follow on Twitter | http://www.twitter.com/patientpower Follow on Google+ | http://www.google.com/+patientpowerinfo

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In this presentation from the 18th European Congress: Perspectives in Lung Cancer, Dr. Tanja Cufer discusses the treatment of elderly and PS2 patients with lung cancer. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=Lung © 2017 Imedex, LLC.

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In this presentation from the 18th European Congress: Perspectives in Lung Cancer, Dr. Luis Paz-Ares discusses HER-2, BRAF, KRAS, and MET tumors. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=Lung © 2017 Imedex, LLC.

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With the recent news that Sen. John McCain was diagnosed with glioblastoma, Ashley Sumrall, MD, division chief of neuro-oncology at Levine Cancer Institute, explains the most common treatment options for those who have been afflicted by this particularly aggressive form of brain cancer.

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In this presentation from the 21st Annual Perspectives in Thoracic Oncology, Dr. Joshua Bauml discusses whether there has been progress in the treatment of small cell lung cancer (SCLC). Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=Lung © 2017 Imedex, LLC.

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In this presentation from the 21st Annual Perspectives in Thoracic Oncology, Dr. Evan W. Alley discusses the targeting of HER2, BRAF, KRAS, MET, and TRK mutations. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=Lung © 2017 Imedex, LLC.

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In this Velocity Vlog activity, Dr. Howard L. Kaufman of the Rutgers Cancer Institute, provides a brief overview of the incidence and epidemiology of Merkel cell carcinoma and then discusses clinical trial updates from the recent American Society of Clinical Oncology Annual Meeting in Chicago. Earn CME Credit for this activity: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7263 © 2017 Imedex, LLC.

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In this Ask the Expert segment, Dr. Srdan Verstovsek from The University of Texas MD Anderson Cancer Center responds to MPN community member, Susan. Susan asks if there are MPN treatments that reduce fibrosis or slow progression of the disease. Dr. Verstovsek explains the how the treatments work and discusses the possibility of reducing fibrosis and limiting disease progression. Get email alerts | http://www.patientpower.info/alerts Subscribe on YouTube | http://www.youtube.com/patientpower Like on Facebook | http://www.fb.com/patientpower.info Follow on Twitter | http://www.twitter.com/patientpower Follow on Google+ | http://www.google.com/+patientpowerinfo

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In this Ask the Expert segment, a Patient Power community member wants to know if and why a bone marrow biopsy is necessary if her essential thrombocythemia (ET) diagnosis is confirmed through blood work. Dr. Srdan Verstovsek responds by explaining what specific information is provided to the clinician by a bone marrow biopsy, specifically related to fibrosis, disease mutations, and how this information may affect prognosis and treatment. Get email alerts | http://www.patientpower.info/alerts Subscribe on YouTube | http://www.youtube.com/patientpower Like on Facebook | http://www.fb.com/patientpower.info Follow on Twitter | http://www.twitter.com/patientpower Follow on Google+ | http://www.google.com/+patientpowerinfo

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Stereotactic body radiation therapy (SBRT) combined with surgery can be used to treat metastatic kidney cancer, according to Roswell Park researchers. The study is the first clinical trial to evaluate the immune effects of high-dose radiation therapy followed by surgery in patients with advanced kidney cancer, and may also set the stage for combination treatments incorporating immunotherapy. Learn more: https://goo.gl/RKj5Pf

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George R. Simon, MD, FACP, FCCP of MD Anderson Cancer Center gives an overview of the Checkmate 032 and CTONG 1104 studies on non-small cell lung cancer. This was recorded at the 2017 Annual Meeting Annual Meeting in Chicago, IL.         non-small cell lung cancer checkmate 032, checkmate 032, ctong 1104, checkmate 032 and ctong 1104 studies, 2017 annual meeting

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Christopher J. Logothetis, MD of MD Anderson Cancer Center compares the three trials, CHAARTED, STAMPEDE, and LATITUDE, and discusses how clinicians choose between chemotherapies for patients with prostate cancer. This was recorded at the 2017 Annual Meeting Annual Meeting in Chicago, IL.

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Nancy Dawson, MD of Lombardi Cancer Center at Georgetown University Hospital gives an overview of the STAMPEDE study, which focuses on the use of abiraterone acetate in the treatment of prostate cancer. This was recorded at the 2017 Annual Meeting Annual Meeting in Chicago, IL.

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H. Jack West, MD of Swedish Cancer Institute gives an overview of the use of gefinitib compared to standard chemotherapy (vinorelbine+cisplatin) as adjuvant treatment for patients with non-small cell lung cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 8500: Gefitinib (G) versus vinorelbine+cisplatin (VP) as adjuvant treatment in stage II-IIIA (N1-N2) non-small-cell lung cancer (NSCLC) with EGFR-activating mutation (ADJUVANT): A randomized, Phase III trial (CTONG 1104)

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H. Jack West, MD of Swedish Cancer Institute discusses the updated results of the KEYNOTE-021 study for patients with advanced nonsquamous non-small cell lung cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9094: First-line carboplatin and pemetrexed (CP) with or without pembrolizumab (pembro) for advanced nonsquamous NSCLC: Updated results of KEYNOTE-021 cohort G.

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H. Jack West, MD of Swedish Cancer Institute discusses an abstract that focused on the efficacy and safety of a third generation ALK inhibitor, lorlatinib, for ALK positive non-small cell lung cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9006: Efficacy and safety of lorlatinib in patients (pts) with ALK+ non-small cell lung cancer (NSCLC) with one or more prior ALK tyrosine kinase inhibitor (TKI): A phase I/II study

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology discusses the take home of the POLLUX and CASTOR trials, which is the importance of early triplet therapy for relapsed patients. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 8006: Efficacy of daratumumab in combination with lenalidomide plus dexamethasone (DRd) or bortezomib plus dexamethasone (DVd) in relapsed or refractory multiple myeloma (RRMM) based on cytogenetic risk status

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology argues that the take-home message for the follow-up on the RESONATE trial is the role of ibrutinib for all types of CLL patients. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 7510: Long-term efficacy and safety with ibrutinib (ibr) in previously treated chronic lymphocytic leukemia (CLL): Up to four years follow-up of the RESONATE study.

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology discusses the take-home message of the LATITUDE study at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract LBA3: LATITUDE: A phase III, double-blind, randomized trial of androgen deprivation therapy with abiraterone acetate plus prednisone or placebos in newly diagnosed high-risk metastatic hormone-naive prostate cancer

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology gives an overview of the POLLUX/CASTOR studies, which looked at daratumumab in combination with lenalidomide plus dexamethasone (DRd) and bortezomib plus dexamethasone in relapsed and refractory multiple myeloma. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 8006: Efficacy of daratumumab in combination with lenalidomide plus dexamethasone (DRd) or bortezomib plus dexamethasone (DVd) in relapsed or refractory multiple myeloma (RRMM) based on cytogenetic risk status

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology discusses the LATITUDE trial, a phase III trial on androgen deprivation therapy (ADT) with abiraterone in newly diagnosed, high-risk, metastatic prostate cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract LBA3: LATITUDE: A phase III, double-blind, randomized trial of androgen deprivation therapy with abiraterone acetate plus prednisone or placebos in newly diagnosed high-risk metastatic hormone-naive prostate cancer

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology gives an overview a four year follow-up study on the use of ibrutinib in previously treated patients with Chronic Lymphocytic Leukemia (CLL). This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 7510: Long-term efficacy and safety with ibrutinib (ibr) in previously treated chronic lymphocytic leukemia (CLL): Up to four years follow-up of the RESONATE study

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology summarizes common questions that are asked regarding the updates study on the RESONATE trial, which was presented at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 7510: Long-term efficacy and safety with ibrutinib (ibr) in previously treated chronic lymphocytic leukemia (CLL): Up to four years follow-up of the RESONATE study

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology explains a common question that’s usually asked regarding the CASTOR/POLLUX study, which is whether or not you can split the dosing of daratumumab. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 8006: Efficacy of daratumumab in combination with lenalidomide plus dexamethasone (DRd) or bortezomib plus dexamethasone (DVd) in relapsed or refractory multiple myeloma (RRMM) based on cytogenetic risk status

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Mark Wildgust, Vice President of Global Medical Affairs for Janssen Oncology explains which combination improved survival for patients with prostate cancer: androgen deprivation therapy plus abiraterone or androgen deprivation therapy plus docetaxel. He argues ADT plus abiraterone, but it ultimately depends on the physician and patient. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract LBA3: LATITUDE: A phase III, double-blind, randomized trial of androgen deprivation therapy with abiraterone acetate plus prednisone or placebos in newly diagnosed high-risk metastatic hormone-naive prostate cancer

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Katja Weisel, MD of Janssen Oncology gives an overview of her abstract, which focuses on two randomized phase III trials in relapsed or refractory multiple myeloma. DRd (POLLUX) or DVd (CASTOR) significantly improved PFS and deepened responses compared with Rd or Vd alone. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 8006: Efficacy of daratumumab in combination with lenalidomide plus dexamethasone (DRd) or bortezomib plus dexamethasone (DVd) in relapsed or refractory multiple myeloma (RRMM) based on cytogenetic risk status

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Liza Villaruz, MD of University of Pittsburgh Medical Center discusses the next steps for the clinical trial at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract TPS9105: Phase II clinical trial of atezolizumab (A) in advanced non-small cell lung cancer (NSCLC) patients (pts) previously treated with PD1-directed therapy

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Liza Villaruz, MD of University of Pittsburgh Medical Center discusses the impact of atezolizumab on clinical practice and future clinical research at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract TPS9105: Phase II clinical trial of atezolizumab (A) in advanced non-small cell lung cancer (NSCLC) patients (pts) previously treated with PD1-directed therapy

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Liza Villaruz, MD of University of Pittsburgh Medical Center gives an overview of her presentation, which focuses on the use of atezolizumab in advanced non-small cell lung cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract TPS9105: Phase II clinical trial of atezolizumab (A) in advanced non-small cell lung cancer (NSCLC) patients (pts) previously treated with PD1-directed therapy

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Jalaja Potluri, MD of AbbVie Inc. gives an overview of her abstract, a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Venetoclax Combined with Azacitidine Versus Azacitidine in Treatment-Naïve Patients with Acute Myeloid Leukemia, which was presented at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract TPS7069: Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Venetoclax Combined with Azacitidine Versus Azacitidine in Treatment-Naïve Patients with Acute Myeloid Leukemia

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Robert Petit, MD, Chief Scientific Officer of Advaxis, Inc. gives an overview of Advaxis’ Lm Technology, which alters Listeria monocytogenes (Lm) bacteria to stimulate cancer-fighting T-cells directed against cancer antigens. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL.

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Aly-Khan Lalani, MD of Dana-Farber Cancer Institute discusses the next steps for his study, which include combining c-met targeted therapies with immunotherapy. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 4573: Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma (ccRCC) and its association with PD-L1 expression

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Aly-Khan Lalani, MD of Dana-Farber Cancer Institute gives an overview of his presentation, Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma (ccRCC) and its association with PD-L1 expression, at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 4573: Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma (ccRCC) and its association with PD-L1 expression

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Aly-Khan Lalani, MD of Dana-Farber Cancer Institute summarizes the common questions colleagues ask him concerning his study on c-Met expression in renal cell carcinoma. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 4573: Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma (ccRCC) and its association with PD-L1 expression

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Mark M. Awad, MD, PhD of Dana-Farber Cancer Institute gives an overview of his abstract, Impact of MET inhibitors on survival among patients (pts) with MET exon 14 mutant (METdel14) non-small cell lung cancer (NSCLC), at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 8511: Impact of MET inhibitors on survival among patients (pts) with MET exon 14 mutant (METdel14) non-small cell lung cancer (NSCLC)

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Mark M. Awad, MD, PhD of Dana-Farber Cancer Institute summarizes the next steps for METdel14 mutations and MET inhibitors for non-small cell lung cancer at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 8511: Impact of MET inhibitors on survival among patients (pts) with MET exon 14 mutant (METdel14) non-small cell lung cancer (NSCLC)

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J. Thaddeus Beck, MD, FACP of Highlands Oncology Group gives an overview of his presentation, which focused on the use of IBM Watson technology for clinical trial matching at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 6501: Cognitive technology addressing optimal cancer clinical trial matching and protocol feasibility in a community cancer practice

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Shailender Bhatia, MD of Seattle Cancer Care Alliance discusses his second presentation, which focused on the use of nivolumab plus an anti-LAG 3 antibody for the treatment of metastatic melanoma at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 9520: Initial efficacy of anti-lymphocyte activation gene-3 (antiLAG-3; BMS-986016) in combination with nivolumab (nivo) in pts with melanoma (MEL) previously treated with antiPD-1/PD-L1 therapy

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Aditya Bardia, MD, MPH of Harvard Medical School and Massachusetts General Hospital Cancer Center gives an overview of the treatment trends for 2017 in breast cancer treatment. He discusses two promising clinical trials on breast cancer that were presented at the 2017 ASCO Annual Meeting in Chicago, IL.

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Aditya Bardia, MD, MPH of Harvard Medical School and Massachusetts General Hospital Cancer Center gives an overview of his presentation, Evaluation of RAD1901, a novel investigational, selective estrogen receptor degrader (SERD), for the treatment of ER-positive (ER+) advanced breast cancer, which was presented at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 1014: Evaluation of RAD1901, a novel investigational, selective estrogen receptor degrader (SERD), for the treatment of ER-positive (ER+) advanced breast cancer

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Aditya Bardia, MD, MPH of Harvard Medical School and Massachusetts General Hospital Cancer Center discusses common questions he’s asked regarding his study on the use of elacestrant (RAD1901) for ER+ advanced breast cancer. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 1014: Evaluation of RAD1901, a novel investigational, selective estrogen receptor degrader (SERD), for the treatment of ER-positive (ER+) advanced breast cancer

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Adi Diab, MD of MD Anderson Cancer Center gives an overview of his abstracts, which focus on the use of NKTR-214 for treatment of patients with renal cell carcinoma and melanoma. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract e14040: A phase 1/2 study of a novel IL-2 cytokine, NKTR-214, and nivolumab in patients with select locally advanced or metastatic solid tumors Abstract 2545: Effect of a novel IL-2 cytokine immune agonist (NKTR-214) on proliferating CD8+T cells and PD-1 expression on immune cells in the tumor microenvironment in patients with prior checkpoint therapy

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Steven E. Benner, MD, Senior Vice President and Global Therapeutic Head for Oncology at Astellas Oncology discusses whether or not there is a phase 3 trial in the works for the use of gilteritinib for treatment of relapsed/refractory acute myeloid leukemia. This was recorded at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 7003: Deep molecular response to gilteritinib to improve survival in FLT3 mutation-positive relapsed/refractory acute myeloid leukemia

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Steven E. Benner, MD, Senior Vice President and Global Therapeutic Head for Oncology at Astellas Oncology discusses a phase 1 study of enfortumab vedotin for metastatic urothelial cancer, which was presented by Daniel Peter Petrylak, MD of Yale Cancer Center at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 106: A phase 1 study of enfortumab vedotin (ASG-22CE; ASG-22ME): Updated analysis of patients with metastatic urothelial cancer

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Steven E. Benner, MD, Senior Vice President and Global Therapeutic Head for Oncology at Astellas Oncology gives an overview of the results of the FAST Phase 2 Trial, which was presented by Martin H. Schuler, MD at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 4028: Expression of Claudin 18.2 and HER2 in gastric, gastroesophageal junction (GEJ), and esophageal cancers: Results from the FAST Study

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Steven E. Benner, MD, Senior Vice President and Global Therapeutic Head for Oncology at Astellas Oncology discusses the use of enzalutamide for men with metastatic castration-resistant prostate cancer. This abstract was presented by Gerhardt Attard, MD, PhD of The Institute of Cancer Research at the 2017 ASCO Annual Meeting in Chicago, IL. Abstract 5004: A Phase IV, randomized, double-blind, placebo (PBO)-controlled study of continued enzalutamide (ENZA) post prostate-specific antigen (PSA) progression in men with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC)

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Steven E. Benner, MD, Senior Vice President and Global Therapeutic Head for Oncology at Astellas Oncology gives an overview of an abstract presented by Jessica K. Altman, MD of Feinberg School of Medicine at Northwestern University, which focuses on gilteritinib for FLT3 mutation-positive relapsed/refractory acute myeloid leukemia. Abstract 7003: Deep molecular response to gilteritinib to improve survival in FLT3 mutation-positive relapsed/refractory acute myeloid leukemia

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