Author: Editor

In this episode of The Onco’Zine Brief Peter Hofland, Ph.D. talks with Tim Blauwkamp, Ph.D., Chief Scientific Officer and co-founder of Karius.Karius, based in Redwood City, CA, has developed a non-invasive liquid biopsy, a blood test, called the Karius Test®. The test is based on next-generation sequencing of microbial cell-free DNA and can rapidly detect pathogens causing serious infections, including those diseases that are difficult to diagnose through conventional methods. The test can identify and quantify over 1,000 clinically relevant pathogens, including bacteria, DNA viruses, fungi, and parasites. The test can be used to identify infections related to complicated and…

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In this edition of The Onco’Zine Brief, Peter Hofland, Ph.D., talks with Vince McRuiz and Margo Shoup, MD, FACS.Margo Shoup is a nationally recognized surgical oncologist who specializes in gastrointestinal cancers and sarcomas. She is also the senior vice president, and system chair of the Nuvance Health Cancer Institute, where she provides strategic and clinical leadership for all aspects of Nuvance Health’s cancer services.Vince McRuiz is a patient of Dr. Shoup.In March 2020 just as the COVID-19 pandemic was ramping up in the northeastern United States, Vince was diagnosed with a retroperitoneal sarcoma — a rare abdominal cancer —that develops…

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In this edition of The Onco’Zine Brief Peter Hofland, Ph.D. talks with Armon Sharei, Ph.D. Chief Executive Officer of SQZ Biotech, about the development and manufacturing of cell therapies. Traditionally, the foundation of cancer treatment included surgery, chemotherapy, and radiation therapy. But over the last few decades, targeted therapies —drugs that specifically, target molecular changes seen primarily on cancer cells—have become a standard treatment for many cancers. In addition, over the past several years, immunotherapies—therapies that are designed to use the power of a patient’s own immune system to attack cancer, have emerged as a new treatment. One of the…

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In this edition of The Onco’Zine Brief Peter Hofland, Ph.D. talks with Cristian Massacesi, MD, Senior Vice President, Head of Late Development Oncology R&D at AstraZeneca and with Jeffrey Skolnik, MD, Vice President, Clinical Development at Inovio Pharmaceuticals about new data and exciting developments both companies are presenting during the 2020 virtual annual meeting of the American Society of Clinical Oncology – ASCO.This year, amidst the SAR-CoV-2 or coronavirus pandemic, the ASCO organization has been hard at work to offer a unique scientific program for oncology professionals, patient advocates, and industry representatives.In the program, Hofland and Massacesi talk about AZD9833,…

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In this edition of The Onco’Zine Brief, Peter Hofland talking with Helen Sabzevari, the president of Precigen. Precigen is a biopharmaceutical company dedicated to the discovery and clinical-stage development of the next generation of gene and cell therapies using precision technology. The company is developing novel therapeutic agents that are designed to target the most urgent and difficult diseases in immuno-oncology, autoimmune disorders, and infectious diseases.During the second part of the virtual meeting of the American Association of Clinical Research – AACR – being held June 22 to June 24, 2020, the company presented preclinical results of an investigational drug…

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In this episode of The Onco’Zine Brief, Peter Hofland talks with Thorsten Sperber, Global Head Medical Affairs at Immunomedics. Hofland and Sperber talk about sacituzumab govitecan, a novel antibody-drug conjugate. At the time of the interview, the drug was not yet approved, but in the weeks following the interview, the U.S. Food and Drug Administration (FDA) approved sacituzumab govitecan (Trodelvyâ„¢) for the treatment of adult patients with metastatic triple-negative breast cancer (mTNBC) who have received at least two prior therapies for patients with relapsed or refractory metastatic disease.Sacituzumab govitecan, previously known as IMMU-132, is Immunomedics’ lead product and the most…

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In this episode of The Onco’Zine Brief, Peter Hofland talks with Terri Conneran, a lung cancer survivor and patient advocate. Struggling in the heat and humidity of the summer of 2016, Terri Conneran believed that her asthma was uncontrolled. In August that year, her physician assistant prescribed her a preventive inhaler. That autumn brought the excuse of allergies, plus time for the new inhaler to take effect. By Christmas 2016, nasal congestion, and a heavy feeling chest with shortness of breath it was time to again see her doctor. Hearing fluid in her lungs, an x-ray showed a mass with…

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In this episode of The Onco’Zine Brief, recorded during the 42nd San Antonio Breast Cancer Symposium (SABCS) held December 10 – 14, 2019 in San Antonio, Texas, Peter Hofland talks with Susan Rafte, a 25+ year survivor of metastatic breast cancer and patient advocate.In 1994, eight and a half months after birth to her daughter Marika, Susan Rafte, only 30 years old, was diagnosed with stage III ductal carcinoma.While she was pregnant with her daughter, she first felt a lump in her breast. Her doctors attributed the lump to her pregnancies. However, 18 months later, when Rafte pushed for a…

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In this edition of The Onco’Zine Brief, recorded during the 42nd San Antonio Breast Cancer Symposium (SABCS), held December 10 – 14, 2019 in San Antonio, Texas, Peter Hofland talks with leading breast cancer experts and patients about metastatic breast cancer and health-related quality of life hrQoL issues including sexual intimacy, bone health and joint pain. In this roundtable, panelists will also discuss liquid biomarkers for disease progression in the metastatic setting.The expert panel includes; David Portman, MD, founder and Chief Executive Officer (CEO) of Sermonix Pharmaceuticals. Portman is a respected Key Opinion Leader (KOL) in the field, presented clinical…

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In this edition of The Onco’Zine Brief Peter Hofland talks with Catherine Ivy, the Founder and President of the Ben & Catherine Ivy Foundation. The Ben & Catherine Ivy Foundation, established in 2005, is the largest non-government organization supporter of brain tumor – including glioblastoma (GBM) – research in the world. To date, the Ivy Foundation has funded clinical trials and basic science in North America, Europe, and Asia.  Glioblastoma, also known as glioblastoma multiforme, is an aggressive type of cancer that can occur in the brain or spinal cord. Glioblastoma forms from cells called astrocytes, that support nerve cells. The…

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Raj Malik, MD – G1 Therapeutics discusses G1 Therapeutics to present data showing myelopreservation benefits of Trilaciclib in patients with small cell lung cancer at the ASCO20 Virtual Scientific Program. http://investor.g1therapeutics.com/news-releases/news-release-details/g1-therapeutics-present-data-showing-myelopreservation-benefits

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Radek Spisek, Ph.D. SOTIO discusses SO-C101 displays strong anti-tumor effect in TC-1 and TRAMP-C2 tumor mice and in combination with PD-1 blockade prevents tumor development in a NK and CD8+ T cells dependent manner Summary: SO-C101 is a IL-15 superagonist being developed for the treatment of advanced solid tumors – currently in an ongoing Phase 1 trial (NCT04234113) – Poster shows new preclinical data detailing anti-tumor efficacy in tumor mouse models – SO-C101 monotherapy significant reduced tumor growth in early and advanced treatment settings – SO-C101 in combination with PD-1 inhibitors led to durable tumor response in a majority of…

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Radek Spisek, Ph.D. SOTIO discusses SO-C101 displays strong anti-tumor effect in TC-1 and TRAMP-C2 tumor mice and in combination with PD-1 blockade prevents tumor development in a NK and CD8+ T cells dependent manner Summary: SO-C101 is a IL-15 superagonist being developed for the treatment of advanced solid tumors – currently in an ongoing Phase 1 trial (NCT04234113) – Poster shows new preclinical data detailing anti-tumor efficacy in tumor mouse models – SO-C101 monotherapy significant reduced tumor growth in early and advanced treatment settings – SO-C101 in combination with PD-1 inhibitors led to durable tumor response in a majority of…

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Radek Spisek, Ph.D. SOTIO discusses SO-C101 displays strong anti-tumor effect in TC-1 and TRAMP-C2 tumor mice and in combination with PD-1 blockade prevents tumor development in a NK and CD8+ T cells dependent manner Summary: SO-C101 is a IL-15 superagonist being developed for the treatment of advanced solid tumors – currently in an ongoing Phase 1 trial (NCT04234113) – Poster shows new preclinical data detailing anti-tumor efficacy in tumor mouse models – SO-C101 monotherapy significant reduced tumor growth in early and advanced treatment settings – SO-C101 in combination with PD-1 inhibitors led to durable tumor response in a majority of…

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Radek Spisek, Ph.D. SOTIO discusses SO-C101 displays strong anti-tumor effect in TC-1 and TRAMP-C2 tumor mice and in combination with PD-1 blockade prevents tumor development in a NK and CD8+ T cells dependent manner Summary: SO-C101 is a IL-15 superagonist being developed for the treatment of advanced solid tumors – currently in an ongoing Phase 1 trial (NCT04234113) – Poster shows new preclinical data detailing anti-tumor efficacy in tumor mouse models – SO-C101 monotherapy significant reduced tumor growth in early and advanced treatment settings – SO-C101 in combination with PD-1 inhibitors led to durable tumor response in a majority of…

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Jason Luke, MD, FACP, is an associate professor of medicine in the Division of Hematology/Oncology at the University of Pittsburgh School of Medicine and the director of the Cancer Immunotherapeutics Center within the UPMC Hillman Cancer Center Immunology and Immunotherapy Program discusses A phase I, first-in-human, open-label, dose-escalation study of MGD013.

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Jason Luke, MD, FACP, is an associate professor of medicine in the Division of Hematology/Oncology at the University of Pittsburgh School of Medicine and the director of the Cancer Immunotherapeutics Center within the UPMC Hillman Cancer Center Immunology and Immunotherapy Program discusses A phase I, first-in-human, open-label, dose-escalation study of MGD013.

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Jason Luke, MD, FACP, is an associate professor of medicine in the Division of Hematology/Oncology at the University of Pittsburgh School of Medicine and the director of the Cancer Immunotherapeutics Center within the UPMC Hillman Cancer Center Immunology and Immunotherapy Program discusses A phase I, first-in-human, open-label, dose-escalation study of MGD013

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Jason Luke, MD, FACP, is an associate professor of medicine in the Division of Hematology/Oncology at the University of Pittsburgh School of Medicine and the director of the Cancer Immunotherapeutics Center within the UPMC Hillman Cancer Center Immunology and Immunotherapy Program, discusses A phase I, first-in-human, open-label, dose-escalation study of MGD013.

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Total glossectomy is a surgical option for patients with advanced (stage IV cancers) or recurrent tongue cancer. Advanced cancer of the tongue has severe repercussions to function and survival of the affected patients. This procedure is most commonly performed for oncologic control. CASE REPORT The patient, a 53-year-old male affected by carcinoma of base of tongue, was referred to Dr. Mathan Mohan. After extensive clinical and laboratory examination, Dr. Mathan nominated the patient for Total Glossectomy (TG) with PMMC flap reconstruction. RESECTION The procedure of total glossectomy for surgical management of such locally advanced cancer of the tongue is always…

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Buccal cancer involving masticator space grows rapidly and penetrates well with a high recurrence rate due its aggressive nature. The local recurrence rate is very high, and many patients are treated with palliative intent because of their eventual poor outcome. Results are poor because of inability to achieve negative margins in three dimensions. Also, the surgical clearance is difficult because of the extent of tumour spread in masticator space. Cancers originating from the masticator space, pterygoid plates or skull base, invade adjacent anatomical structures, thus surgical tumour resection becomes very challenging. CASE REPORT The present case describes the surgical management…

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Nicolas Poirier, Ph.D. – OSE Immunotherapeutics – discusses Identifies Monoclonal Antibody Antagonists of CLEC-1 as New Checkpoint Inhibitors of Immune Myeloid Cells in Immuno-Oncology and New Data Supporting Bispecific Antibody Checkpoint Inhibitor Platform (BiCKI®) and Bifunctional Therapy Targeting PD-1 and IL-7 (BiCKI®-IL-7) For Cancer Immunotherapy – What is the next step for this research?

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Nicolas Poirier, Ph.D. – OSE Immunotherapeutics – discusses – Identifies Monoclonal Antibody Antagonists of CLEC-1 as New Checkpoint Inhibitors of Immune Myeloid Cells in Immuno-Oncology and New Data Supporting Bispecific Antibody Checkpoint Inhibitor Platform (BiCKI®) and Bifunctional Therapy Targeting PD-1 and IL-7 (BiCKI®-IL-7) For Cancer Immunotherapy.

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Nicholas J. Vogelzang, MD Comprehensive Cancer Centers of Nevada discusses CX-2029, a PROBODY drug conjugate targeting CD71 (transferrin receptor): Results from a first-in-human study (PROCLAIM-CX-2029) in patients (Pts) with advanced prostate cancer and PROCLAIM-CX-072: Analysis of patients with prostate advanced solid tumors receiving long-term treatment with CX-072, a PD-L1 probody therapeutic, as a single agent or in combination with ipilimumab

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Featuring David Gandara, MD and Johannes Kratz, MD Please visit www.oncocyte.com for more information on DetermaRx   2020 has ushered in two important milestones in early-stage lung cancer. First, CMS approved DetermaRx, a molecular test that identifies patients with Stage I-IIA non-squamous NSCLC who are at high risk of recurrence, and may benefit from adjuvant chemotherapy. Second, the ADAURA trial results, presented at ASCO, demonstrated the efficacy of osimertinib in EGFR-positive early-stage NSCLC. In this webinar, we will review these latest research findings as well as ongoing clinical trials on the use of chemotherapy, targeted therapy, and immunotherapy in early-stage…

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Timothy A Yap, MD, PhD of MD Anderson Cancer Center @MDAndersonNews discusses AVID200, first-in-class TGF-beta 1 and 3 selective and potent inhibitor: Safety and biomarker results of a phase I monotherapy dose-escalation study in patients with advanced solid tumors. Read here: https://meetinglibrary.asco.org/record/187808/abstract

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Keith W. Pratz, MD of Penn Medicine @PennMedicine discusses venetoclax plus azacitidine demonstratesstatistically significant overall survival benefit and improved remission rates in treatment-naïve acute myeloid leukemia patients. https://library.ehaweb.org/eha/2020/eha25th/303390/courtney.dinardo.a.randomized.double-blind.placebo-controlled.study.of.html?f=listing%3D0%2Abrowseby%3D8%2Asortby%3D1%2Asearch%3Ddinardo

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Keith W. Pratz, MD of Penn Medicine @PennMedicine discusses venetoclax plus azacitidine demonstratesstatistically significant overall survival benefit and improved remission rates in treatment-naïve acute myeloid leukemia patients. https://library.ehaweb.org/eha/2020/eha25th/303390/courtney.dinardo.a.randomized.double-blind.placebo-controlled.study.of.html?f=listing%3D0%2Abrowseby%3D8%2Asortby%3D1%2Asearch%3Ddinardo

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Keith W. Pratz, MD of Penn Medicine @PennMedicine discusses venetoclax plus azacitidine demonstratesstatistically significant overall survival benefit and improved remission rates in treatment-naïve acute myeloid leukemia patients. https://library.ehaweb.org/eha/2020/eha25th/303390/courtney.dinardo.a.randomized.double-blind.placebo-controlled.study.of.html?f=listing%3D0%2Abrowseby%3D8%2Asortby%3D1%2Asearch%3Ddinardo

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Philadelphia, PA (July 21, 2020) – Oncoceutics, a clinical-stage drug discovery and development company, announced today that the U.S. Food and Drug Administration (FDA) has granted Rare Pediatric Disease Designation to Oncoceutics’ investigational cancer drug ONC201 for the treatment of “H3 K27M-mutant glioma”.The Rare Pediatric Disease Priority Review Voucher program, which was created as part of the Food and Drug Administration Safety and Innovation Act (FDASIA) of 2012, is intended to incentivize the development of new therapies for rare pediatric diseases. Should ONC201 be approved by the FDA for H3 K27M-mutant glioma, the Rare Pediatric Disease Designation may enable Oncoceutics…

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Ryan Hartmaier, PhD of AstraZeneca discusses TATTON (savolitinib + osimertinib) – measuring ctDNA clearance as a potential predictor of PFS in EGFRm MET-amplified NSCLC. https://www.ascopost.com/issues/july-25-2020/ctdna-clearance-predicts-progression-free-survival-with-osimertinibsavolitinib-in-egfr-mutant-met-amplified-nsclc/

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Philadelphia, PA (July 22, 2020) – Oncoceutics, a clinical-stage drug discovery and development company, commemorates GBM Awareness Day this July and expresses its support for all those affected by this devastating form of brain cancer. Glioblastoma (GBM) is the most common type of malignant brain tumor among adults and is typically fatal. The two-year survival rate for GBM is less than 20%, and little progress has been made in battling brain cancer over the past 50 years. ONC201, the company’s lead development candidate, is currently being tested in clinical trials for brain cancer, including GBM. Early results for the ONC201 trials…

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Mike Thompson, MD, PhD @mtmdphd of Aurora Cancer Care @Aurora_Cancer discusses global rates of influenza and pneumococcal vaccination in multiple myeloma patients in INSIGHT MM: impact on healthcare resource utilization and overall survival. Read here: https://library.ehaweb.org/eha/2020/eha25th/294884/michael.a.thompson.global.rates.of.influenza.28fv29.and.pneumococcal.28pv29.html?f=listing%3D0%2Abrowseby%3D8%2Asortby%3D1%2Asearch%3Dinsight

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Mike Thompson, MD, PhD @mtmdphd of Aurora Cancer Care @Aurora_Cancer discusses global rates of influenza and pneumococcal vaccination in multiple myeloma patients in INSIGHT MM: impact on healthcare resource utilization and overall survival. Read here: https://library.ehaweb.org/eha/2020/eha25th/294884/michael.a.thompson.global.rates.of.influenza.28fv29.and.pneumococcal.28pv29.html?f=listing%3D0%2Abrowseby%3D8%2Asortby%3D1%2Asearch%3Dinsight

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Mike Thompson, MD, PhD @mtmdphd of Aurora Cancer Care @Aurora_Cancer discusses global rates of influenza and pneumococcal vaccination in multiple myeloma patients in INSIGHT MM: impact on healthcare resource utilization and overall survival. Read here: https://library.ehaweb.org/eha/2020/eha25th/294884/michael.a.thompson.global.rates.of.influenza.28fv29.and.pneumococcal.28pv29.html?f=listing%3D0%2Abrowseby%3D8%2Asortby%3D1%2Asearch%3Dinsight

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Laurence Cooper, MD, PhD on controlled, survival of subjects, and final results in IL-12 in combination with a PD-1 inhibitor subjects with recurrent glioblastoma. All three abstracts were presented at this year’s virtual ASCO. Ziopharm will present updated clinical data from its Phase 1/2 controlled IL-12 program. Data will show clinical results of its IL-12 gene therapy, Ad+V, as a monotherapy and in combination with nivolumab for the treatment of recurrent glioblastoma (rGBM). Phase 1 data from this program have shown that treatment with Ad+V can double the median overall survival of patients with rGBM.

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Laurence Cooper, MD, PhD on controlled, survival of subjects, and final results in IL-12 in combination with a PD-1 inhibitor subjects with recurrent glioblastoma. All three abstracts were presented at this year’s virtual ASCO. Ziopharm will present updated clinical data from its Phase 1/2 controlled IL-12 program. Data will show clinical results of its IL-12 gene therapy, Ad+V, as a monotherapy and in combination with nivolumab for the treatment of recurrent glioblastoma (rGBM). Phase 1 data from this program have shown that treatment with Ad+V can double the median overall survival of patients with rGBM.

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Laurence Cooper, MD, PhD on controlled, survival of subjects, and final results in IL-12 in combination with a PD-1 inhibitor subjects with recurrent glioblastoma. All three abstracts were presented at this year’s virtual ASCO. Ziopharm will present updated clinical data from its Phase 1/2 controlled IL-12 program. Data will show clinical results of its IL-12 gene therapy, Ad+V, as a monotherapy and in combination with nivolumab for the treatment of recurrent glioblastoma (rGBM). Phase 1 data from this program have shown that treatment with Ad+V can double the median overall survival of patients with rGBM.

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Andre Thierry, MD of University Pierre et Marie Curie @UPMC discusses pembrolizumab vs. chemotherapy for microsatellite instability-high/mismatch repair deficient metastatic colorectal cancer: the phase 3 KEYNOTE-177 study presented at this year’s virtual ASCO. Read here: https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.18_suppl.LBA4

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Brigitte C. Widemann, MD and Andrea Gross, MD of National Cancer Institute discuss selumetinib, the first medicine approved to treat paediatric patients with neurofibromatosis type 1 plexiform neurofibromas, a rare and debilitating genetic condition. More here: https://www.astrazeneca.com/media-centre/press-releases/2020/koselugo-selumetinib-approved-in-us-for-paediatric-patients-with-neurofibromatosis-type-1-plexiform-neurofibromas.html

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Brigitte C. Widemann, MD and Andrea Gross, MD of National Cancer Institute discuss selumetinib, the first medicine approved to treat paediatric patients with neurofibromatosis type 1 plexiform neurofibromas, a rare and debilitating genetic condition. More here: https://www.astrazeneca.com/media-centre/press-releases/2020/koselugo-selumetinib-approved-in-us-for-paediatric-patients-with-neurofibromatosis-type-1-plexiform-neurofibromas.html

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Brigitte C. Widemann, MD and Andrea Gross, MD of National Cancer Institute discuss selumetinib, the first medicine approved to treat paediatric patients with neurofibromatosis type 1 plexiform neurofibromas, a rare and debilitating genetic condition. More here: https://www.astrazeneca.com/media-centre/press-releases/2020/koselugo-selumetinib-approved-in-us-for-paediatric-patients-with-neurofibromatosis-type-1-plexiform-neurofibromas.html

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Kevin Harrington, PhD, MBBS, of the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust discusses KEYNOTE-048: progression after the next line of therapy following pembrolizumab or P plus chemotherapy vs EXTREME as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma. Read here: https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.6505

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Kevin Harrington, PhD, MBBS, of the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust discusses KEYNOTE-048: progression after the next line of therapy following pembrolizumab or P plus chemotherapy vs EXTREME as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma. Read here: https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.6505

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Kevin Harrington, PhD, MBBS, of the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust discusses KEYNOTE-048: progression after the next line of therapy following pembrolizumab or P plus chemotherapy vs EXTREME as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma. Read here: https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.6505

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Margaret von Mehren, MD of Fox Chase Cancer Center @FoxChaseCancer discusses the FDA Full Approval of Deciphera Pharmaceuticals’ QINLOCK for the Treatment of Fourth-Line Gastrointestinal Stromal Tumor. Read here: https://investors.deciphera.com/news-releases/news-release-details/fda-grants-full-approval-deciphera-pharmaceuticals-qinlocktm

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Dr. Jenni Li joins GRACE as guest faculty to provide updated information to our Mandarin Lung Cancer Video Library, for our mandarin speaking community.In this video, Dr. Li shares information on the role of immunotherapy for unresectable stage 3 non small cell lung cancer.For more, please visit http://cancerGRACE.org/. To join the conversation, visit https://cancergrace.org/forum.

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Chung-Han Lee, MD @ChungHanLee3 of Memorial Sloan Kettering Cancer Center @sloan_kettering discusses the KEYNOTE-146/Study 111: Phase II trial of lenvatinib plus pembrolizumab for disease progression after PD-1/PD-L1 immune checkpoint inhibitor in metastatic clear cell renal cell carcinoma (mccRCC). Read here: https://meetinglibrary.asco.org/record/186053/abstract

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Chung-Han Lee, MD @ChungHanLee3 of Memorial Sloan Kettering Cancer Center @sloan_kettering discusses the KEYNOTE-146/Study 111: Phase II trial of lenvatinib plus pembrolizumab for disease progression after PD-1/PD-L1 immune checkpoint inhibitor in metastatic clear cell renal cell carcinoma (mccRCC). Read here: https://meetinglibrary.asco.org/record/186053/abstract

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Saad Z. Usmani, M.D @szusmani of Levine Cancer Institute @LevineCancer discusses the FDA approval of DARZALEX FASPRO (daratumumab and hyaluronidase-fihj), a new subcutaneous formulation of daratumumab in the treatment of patients with MM. Read here: https://www.prnewswire.com/news-releases/us-food-and-drug-administration-approves-darzalex-faspro-daratumumab-and-hyaluronidase-fihj-a-new-subcutaneous-formulation-of-daratumumab-in-the-treatment-of-patients-with-multiple-myeloma-301051154.html

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Saad Z. Usmani, M.D of Levine Cancer Institute @LevineCancer discusses the FDA approval of DARZALEX FASPRO (daratumumab and hyaluronidase-fihj), a new subcutaneous formulation of daratumumab in the treatment of patients with MM. Read here: https://www.prnewswire.com/news-releases/us-food-and-drug-administration-approves-darzalex-faspro-daratumumab-and-hyaluronidase-fihj-a-new-subcutaneous-formulation-of-daratumumab-in-the-treatment-of-patients-with-multiple-myeloma-301051154.html

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Lionel Ades, MD of St. Louis Hospital discusses the phase II study of pevonedistat + azacitidine vs. A in patients with higher-risk myelodysplastic syndromes/chronic myelomonocytic leukemia, or low-blast acute myelogenous leukemia presented at this year’s virtual ASCO. ______________ Results from the Phase 2 Pevonedistat-2001 trial will be presented in an oral session at ASCO. The study investigated pevonedistat plus azacitidine versus azacitidine alone in patients with higher-risk myelodysplastic syndromes (HR-MDS), higher-risk chronic myelomonocytic leukemia (HR-CMML) or low blast acute myeloid leukemia (LB-AML).These patients typically have poor prognoses as a result of limited response to available therapies. HR-MDS, in particular, has…

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Lionel Ades, MD of St. Louis Hospital discusses the phase II study of pevonedistat + azacitidine vs. A in patients with higher-risk myelodysplastic syndromes/chronic myelomonocytic leukemia, or low-blast acute myelogenous leukemia presented at this year’s virtual ASCO. ______________ Results from the Phase 2 Pevonedistat-2001 trial will be presented in an oral session at ASCO. The study investigated pevonedistat plus azacitidine versus azacitidine alone in patients with higher-risk myelodysplastic syndromes (HR-MDS), higher-risk chronic myelomonocytic leukemia (HR-CMML) or low blast acute myeloid leukemia (LB-AML).These patients typically have poor prognoses as a result of limited response to available therapies. HR-MDS, in particular, has…

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Ross Camidge, MD, PhD of University of Colorado Cancer Center @CUCancerCenter Takeda’s ALUNBRIG (brigatinib) as a first-line treatment option for patients diagnosed with rare and serious form of lung cancer. Read here: https://www.businesswire.com/news/home/20200522005448/en/U.S.-FDA-Approves-Takeda%E2%80%99s-ALUNBRIG%C2%AE-brigatinib-First-Line

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Ross Camidge, MD, PhD of University of Colorado Cancer Center @CUCancerCenter Takeda’s ALUNBRIG (brigatinib) as a first-line treatment option for patients diagnosed with rare and serious form of lung cancer. Read here: https://www.businesswire.com/news/home/20200522005448/en/U.S.-FDA-Approves-Takeda%E2%80%99s-ALUNBRIG%C2%AE-brigatinib-First-Line

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Ross Camidge, MD, PhD of University of Colorado Cancer Center @CUCancerCenter Takeda’s ALUNBRIG (brigatinib) as a first-line treatment option for patients diagnosed with rare and serious form of lung cancer. Read here: https://www.businesswire.com/news/home/20200522005448/en/U.S.-FDA-Approves-Takeda%E2%80%99s-ALUNBRIG%C2%AE-brigatinib-First-Line  

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Robert Epstein, MD, MS of Epstein Health LLC on real-world burden of chemotherapy-induced myelosuppression: results of a U.S. online survey of patients with cancer. Background/Key Findings: 301 people with cancer (breast cancer = 153, lung cancer = 100, colorectal cancer = 48) who were treated with chemotherapy in the past year and experienced at least one episode of myelosuppression completed an online survey to assess the impact of chemotherapy-induced myelosuppression. Nearly nine in ten (89%) survey participants reported that myelosuppression had a moderate or major impact on their lives (moderate life impact = 49%, major life impact = 40%). Fatigue…

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Robert Epstein, MD, MS of Epstein Health LLC on real-world burden of chemotherapy-induced myelosuppression: results of a U.S. online survey of patients with cancer. Background/Key Findings:   301 people with cancer (breast cancer = 153, lung cancer = 100, colorectal cancer = 48) who were treated with chemotherapy in the past year and experienced at least one episode of myelosuppression completed an online survey to assess the impact of chemotherapy-induced myelosuppression. Nearly nine in ten (89%) survey participants reported that myelosuppression had a moderate or major impact on their lives (moderate life impact = 49%, major life impact = 40%).…

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Robert Epstein, MD, MS of Epstein Health LLC on real-world burden of chemotherapy-induced myelosuppression: results of a U.S. online survey of patients with cancer. Background/Key Findings: 301 people with cancer (breast cancer = 153, lung cancer = 100, colorectal cancer = 48) who were treated with chemotherapy in the past year and experienced at least one episode of myelosuppression completed an online survey to assess the impact of chemotherapy-induced myelosuppression. Nearly nine in ten (89%) survey participants reported that myelosuppression had a moderate or major impact on their lives (moderate life impact = 49%, major life impact = 40%). Fatigue…

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