Disease monitoring is important to determine what is happening with patients outside of the clinical setting. Speaking from the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA, Francesco Lo-Coco, MD, of University Tor Vergata, Rome, Italy, proposes new initiatives that aim to create a better photograph of whats happening in real life in patients with acute promyelocytic leukemia (APL). He explains his idea of a common European case report form (CRF), which would capture the events that occur between the first symptoms of APL to death.