Rafael Fonseca, MD from the Mayo Clinic, Scottsdale, AZ discusses highlights in multiple myeloma (MM) at the American Society of Oncology (ASCO) 2016 Annual Meeting held in Chicago, IL. Prof Fonesca mentions presentations looking at the role of stem cell transplant vs conventional therapy, a meta-analysis on the use of maintenance with lenalidomide and a presentation on a dynamic approach to monitoring patients with smouldering myeloma.