In this interview, Bart Biemond, MD, PhD, from the Academic Medical Centre, Amsterdam, Netherlands, provides an insight is provided into current and prospective therapies for sickle cell disease (SCD). Combining different treatment modalities is the current goal to tackle SCD; however, as improvements are being seen, with survival rates increasing in all patient populations, there is a corresponding increase in complications and side effects, and despite these improvements there have not been any new drug approvals in the last 20 years. Dr Biemond emphasizes his hope for the future of SCD treatment. This video was recorded at the British Society for Haematology (BSH) 2018 Annual Scientific Meeting, held in Liverpool, UK.