In this interview, Torsten Haferlach, MD, of MLL Munich Leukemia Laboratory, Munich, Germany, speaks about the difficulties in diagnosing and treating particular subsets of acute lymphoblastic leukemia (ALL); he explains that this is because there are a plethora of different genetic factors that influence the way in which patients should be treated. This video was recorded at the 2018 European School of Hematology (ESH) Clinical Updates on Acute Leukemias, held in Budapest, Hungary.