The exciting 100,000 Genomes Project has the potential to transform the way patients are cared for. Speaking from the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA, Anna Schuh, MD, PhD, from the University of Oxford, UK, discusses the main aims of the project, including access to genetic testing, identification of therapy response markers and database creation. Prof. Schuh emphasizes the wide-reaching impacts of the project, transforming the UK genomics industry.