The effective use of the correct medication can greatly improve the chance of remission for patients with acute myeloid leukemia (AML). In this insightful video, Lars Bullinger, MD, from Charité University of Medicine, Berlin, Germany, speaking from the International Conference of Acute Myeloid Leukaemia 2017 in Estoril, Portugal by the European School of Hematology (ESH), highlights the optimal combination therapies to combat AML in elderly patients and speculates about the future of this area.