In this interview, recorded at the 2018 Society of Hematologic Oncology (SOHO) Annual Meeting in Houston, TX, Meletios Dimopoulos, MD, of the University of Athens School of Medicine, Athens, Greece, gives an update on multiple myeloma (MM) bone disease, and focuses on imaging techniques and new treatment approaches. Dr Dimopoulos highlights the best imaging modalities for disease identification and monitoring, including low-dose CT, PET-CT, and magnetic resonance imaging. In the field of treatment, he discusses the drawbacks of bisphosphonates and speaks about a trial (NCT01345019) comparing denosumab and zoledronic acid in treating skeletal-related events.