Targeting B-cell receptor signaling in lymphoid malignancies

Wyndham Wilson, MD, PhD from the National Cancer Institute, Bethesda, MD talks about the new developments in the fields of chronic lymphocytic leukemia (CLL), mantle cell lymphoma and large B-cell lymphoma. In particular, new drugs targeting B-cell receptor (BCR) signaling, such as ibrutinib (Brutton tyrosine kinase inhibitor), idelalisib (PI3K-delta inhibitor). Other diseases such as mantle cell lymphoma and activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL), have also been shown to be dependent of BCR signaling, indicating that patients can benefit from similar drugs.