There has been a genome-wide initiative to identify the copy number variants and mutational drivers of multiple myeloma. In this exciting interview, Gareth Morgan, MD, FRCP, FRCPath, PhD, from the UAMS Myeloma Institute, Little Rock, AR, highlights the simplicity yet effectiveness of this initiative for determining prognosis and identifiying high-risk patients. This video was recorded at the Myeloma 2017 meeting in Edinburgh, UK.