This is an exciting time for acute myeloid leukemia (AML), with the introduction of numerous novel combination therapies and the overall survival of patients increasing. In this intriguing video, Mark Levis, MD, PhD, from The Johns Hopkins Hospital, Baltimore, MD, speaking from the International Conference on Acute Myeloid Leukemia 2017 in Estoril, Portugal by the European School of Hematology (ESH), discusses the most promising combination therapies and why he thinks that overall survival is increasing in AML.