Clinical access to new technologies, such as next-generation sequencing (NGS), can revolutionize the treatment of cancer. In this interview, Guillermo Garcia-Manero, MD, of the University of Texas MD Anderson Cancer Center, Houston, TX, eloquently highlights the potential of NGS for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Dr Garcia-Manero emphasizes the power of this tool for predictive screening, among a range of other utilities. This video was recorded at the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA.