Sequential triple-T therapy is a regimen consisting of tailored and targeted treatment aiming for total eradication of minimal residual disease (MRD). Here, Barbara Eichhorst, MD, of the University Hospital Cologne, Cologne, Germany, provides an overview of the Phase II CLL2-BIO study (NCT02689141) of bendamustine, ofatumumab and ibrutinib in treatment-naïve and relapsed/refractory chronic lymphocytic leukemia (CLL) patients. Dr Eichhorst highlights the promising results of this sequential regimen. This interview was recorded at the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA.