Jacob Kettle, PharmD, BCOP, of the University of Missouri Health Care, Columbia, MO, discusses the different ways in which pharmacists can overcome the uncertainties surrounding new tools, such as PD-L1 testing. Pharmacists are encouraged to be aware of the correct applications of these tools by identifying the patients who are most likely to benefit from them, as well as the limitations of each test. This interview was filmed at the 2018 Hematology/Oncology Pharmacy Association (HOPA) Annual Conference held in Denver, CO.